AMiNDR: A Month in Neurodegenerative Disease Research

183 - Changes to Gene Expression in Alzheimer's Disease: June 2021

Episode Summary

We know how critical gene expression and its regulation is to cellular homeostasis. In light of that, it is imperative that we discuss the possibility that Alzheimer’s disease could be caused by disturbances in DNA methylation in certain genes and the potential role of methylation in being a biomarker in AD. In today's episode, Marcia brings you the latest research on this topic, summarizing 9 papers from June 2021. Sections in this episode: Transcription and differential gene expression (02:12) Methylation (09:56) Multiomics (13:29)

Episode Notes

We know how critical gene expression and its regulation is to cellular homeostasis. In light of that, it is imperative that we discuss the possibility that Alzheimer’s disease could be caused by disturbances in DNA methylation in certain genes and the potential role of methylation in being a biomarker in AD. In today's episode, Marcia brings you the latest research on this topic, summarizing 9 papers from June 2021.  

Sections in this episode:  

Transcription and differential gene expression (02:12)  

Methylation (09:56)  

Multiomics (13:29) 

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You can find the numbered bibliography for this episode by clicking here, or the link below:

https://drive.google.com/file/d/1BSe4TcCZV81tH38PS4dY56JXewbBsYCy/view?usp=sharing

To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:

https://drive.google.com/drive/folders/1N1zx_itPkCDNYE1yFGZzQxDDR-NiRx3p?usp=sharing

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We would like to thank our amazing team for all of the work that goes into every episode of AMiNDR. Today's episode was scripted and hosted by Marcia Jude, edited by Lara Onbasi, and reviewed by Ellen Koch. The bibliography was created by Jacques Ferreira and wordcloud (wordart.com) generated by Sarah Louadi. 

Big thanks to the sorting team for sorting all the papers published in June into themes for our episodes: Jacques Ferreira, Elyn Rowe, Ellen Koch, Christy Yu, Nicole Corso, Sarah Louadi, and Naila Kuhlmann. 

Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, and Jacques Ferreira, for keeping everything running smoothly.

Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   

https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   

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*About AMiNDR: *  

Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!"