AMiNDR: A Month in Neurodegenerative Disease Research

217 - Autophagy & Proteostasis in Alzheimer's Disease: August 2021

Episode Summary

Are you familiar with protein aggregation in Alzheimer's disease, but want to learn more about the mechanisms cells use to fight back against these stubborn species? Join Kate in exploring the landscape of cellular processes governing proteostasis and autophagy as they relate to AD. In this short-but-sweet episode, we'll cover a total of 7 papers focused on AD pathology involving autophagy and/or proteostasis dysfunction, as well as treatments targeting these processes. If you're new to these terms, or in need of a cell bio refresher, don't sweat it! - we'll be kicking off the episode with a quick primer on both topics, so sit back and enjoy! Sections in this episode: Proteostasis and Autophagic Dysregulation in AD Pathology (4:57) Targeting Proteostasis or Autophagy for Treatments in AD (16:05)

Episode Notes

Are you familiar with protein aggregation in Alzheimer's disease, but want to learn more about the mechanisms cells use to fight back against these stubborn species? Join Kate in exploring the landscape of cellular processes governing proteostasis and autophagy as they relate to AD. In this short-but-sweet episode, we'll cover a total of 7 papers focused on AD pathology involving autophagy and/or proteostasis dysfunction, as well as treatments targeting these processes. If you're new to these terms, or in need of a cell bio refresher, don't sweat it! - we'll be kicking off the episode with a quick primer on both topics, so sit back and enjoy! 

Sections in this episode:

Proteostasis and Autophagic Dysregulation in AD Pathology (4:57)  

Targeting Proteostasis or Autophagy for Treatments in AD (16:05) 


 

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You can find the numbered bibliography for this episode by clicking here, or the link below:

https://drive.google.com/file/d/1Nr17J1VmMX1BZjYYi3JSTX_maw-UDs3t/view?usp=sharing

To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:

https://drive.google.com/drive/folders/1N1zx_itPkCDNYE1yFGZzQxDDR-NiRx3p?usp=sharing

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Our team of volunteers works together to bring you every episode of AMiNDR. In particular, this episode was scripted and hosted by Kate Van Pelt, edited by Chihiro Abe, and reviewed by Naila Kuhlmann and Ellen Koch. The bibliography was made by Jacques Ferreira and the wordcloud was created by Sarah Louadi (www.wordart.com). 

Big thanks to the sorting team for sorting all the papers published in August 2021 into themes for our episodes: Jacques Ferreira, Ellen Koch, Nicole Corso, Kate Van Pelt, Christy Yu, Dana Clausen and Elyn Rowe. 

Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, and Jacques Ferreira, for keeping everything running smoothly.

Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   

https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   

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If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, audio editing, creating bibliographies, and outreach/marketing. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  

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*About AMiNDR: *  

Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!"