AMiNDR: A Month in Neurodegenerative Disease Research

71 - Amyloid-beta mediated toxicity: Alzheimer's Disease September 2020

Episode Summary

This episode, hosted by Jacques, explores many facets of amyloid-beta mediated toxicity. First, we run through the structure-toxicity relationships of mutant amyloid-beta. Second, we investigate the interaction of amyloid-beta oligomers with membranes and their effect on vesicular trafficking and endocytosis. And lastly, we finish the episode on insights into the effects of amyloid-beta on neurotransmitter systems in AD.

Episode Notes

This episode, hosted by Jacques, explores many facets of amyloid-beta mediated toxicity. First, we run through the structure-toxicity relationships of mutant amyloid-beta. Second, we investigate the interaction of amyloid-beta oligomers with membranes and their effect on vesicular trafficking and endocytosis. And lastly, we finish the episode on insights into the effects of amyloid-beta on neurotransmitter systems in AD. 

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Today's episode was scripted by and hosted by Jacques Ferreira, reviewed by Sarah Louadi, and edited by Ellen Koch. Big thanks to Elyn Rowe and Jacques Ferreira for sorting all the papers published in September into themes for our episodes, and props to the team that  works very hard behind the scenes to make all this possible. 

Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.  

https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w  

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*About AMiNDR: *  

Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!"